1.
Hematol Oncol
; 2022 Dec 27.
Article
in English
| MEDLINE | ID: covidwho-2172925
2.
Leuk Lymphoma
; 63(6): 1474-1478, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1671909
3.
Br J Haematol
; 191(2): 207-211, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-652703
ABSTRACT
A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
Subject(s)
CD4-Positive T-Lymphocytes/chemistry , CD8-Positive T-Lymphocytes/chemistry , COVID-19/immunology , Lymphocyte Subsets/chemistry , Lymphopenia/etiology , Programmed Cell Death 1 Receptor/blood , fas Receptor/blood , Adult , Aged , Aged, 80 and over , Aging/blood , Aging/immunology , Apoptosis , COVID-19/blood , COVID-19/complications , Female , Humans , Lymphocyte Count , Male , Middle Aged , Prognosis , SARS-CoV-2
4.
Am J Hematol
; 95(7): 870-872, 2020 07.
Article
in English
| MEDLINE | ID: covidwho-45733